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Zhijian \u2018James\u2019 Chen is an Investigator of Howard Hughes Medical Institute, and Professor in the Department of Molecular Biology at the University of Texas Southwestern Medical Center at Dallas. He is also Director of Inflammation Research Center and George L. MacGregor Distinguished Chair in Biomedical Science at UT Southwestern. Prior to moving to Dallas, Chen was a senior scientist at ProScript Inc. where he helped discover the proteasome inhibitor VELCADE, a medicine used for the treatment of multiple myeloma.<\/p>\n
After joining UT Southwestern in 1997, Chen discovered the regulatory role of ubiquitination in protein kinase activation in the NF-k<\/em>B and MAP kinase pathways. In addition, he discovered the Mitochondrial Antiviral Signaling (MAVS) protein that reveals a new role of mitochondria in immunity. In 2012, Chen discovered cyclic GMP-AMP synthase (cGAS) as a cytosolic DNA sensor and a new cyclic di-nucleotide signaling pathway that mediate innate immune responses in animal cells. For his work, Chen has received numerous honors including the National Academy of Science Award in Molecular Biology (2012), American Society of Biochemistry and Molecular Biology (ASBMB) Merck Award (2015), Lurie Prize in Biomedical Sciences from the Foundation of NIH (2018), Breakthrough Prize in Life Sciences (2019), Switzer Prize (2019), William B. Coley Award for Distinguished Research in Basic and Tumor Immunology (2020), Louisa Gross Horwitz Prize (2023), Albert Lasker Award for Basic Medical Research (2024), Paul Ehrlich and Ludwig Darmstaedter Prize (2025) and Elaine Redding Brinster Prize (2026).<\/p>\n Chen is a member of the National Academy of Sciences and the National Academy of Medicine, and a Fellow of Royal Society.<\/p>\n The Julius Stone Lectureship is intended to promote the advancement of knowledge in immunology as its relates to the skin and skin disease. The Lectureship is also intended to honor Dr. Julius Stone, whose great commitment to the application of new principles of immunology to the benefit of patients with skin disorders is recognized by this award.<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":" Igniting the flame\u2014How DNA triggers immune and inflammatory responses James Chen, PhD Wednesday, May 13, 5:30 – 6:00 PM About the Speaker Zhijian \u2018James\u2019 Chen is an Investigator of Howard Hughes Medical Institute, and Professor in the Department of Molecular Biology at the University of Texas Southwestern Medical Center at Dallas. He is also Director […]<\/p>\n","protected":false},"author":1,"featured_media":20206615,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"About the Julius Stone Lecture<\/h4>\n
Lecture Title: Uncovering mechanisms of hair follicle dermal niche formation in development and regeneration<\/h3>\r\n
Speaker: Peggy Myung, PhD<\/h3>\r\n
When:<\/h4>\r\nThursday, May 14 |\u00a012 p.m.","_et_gb_content_width":"","footnotes":""},"categories":[18],"tags":[],"dipi_cpt_category":[],"class_list":["post-20206430","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-2026-annual-meeting-named-lectures"],"yoast_head":"\n