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Dr. Hunter Shain is an Associate Professor in the Department of Dermatology at the University of California, San Francisco (UCSF), where he is also affiliated with the Helen Diller Family Comprehensive Cancer Center and the Institute of Human Genetics. His research program harnesses cutting-edge genomic and single-cell technologies to investigate how mutations accumulate in human skin cells and fuel the earliest steps of cancer development.<\/p>\n
Shain earned his B.S. in Biochemistry from the University of Illinois at Urbana-Champaign, graduating summa cum laude, before completing his Ph.D. in Cancer Biology at Stanford University. He then pursued postdoctoral training at UCSF, where he began his focus on the genetics and evolution of melanoma. His laboratory now integrates single-cell DNA sequencing, single-cell RNA sequencing, and spatial transcriptomics to create high-resolution maps of skin biology and tumorigenesis.<\/p>\n
A leader in cancer genomics, Shain has made influential contributions to understanding melanoma evolution, cutaneous squamous cell carcinoma, and the mutational processes shaping normal skin. His group reported the first single-cell atlas of mutations in human melanocytes and has shown how normal skin cells can harbor oncogenic mutations long before cancer arises. Currently, he serves as a lead investigator in the NIH Human Tumor Atlas Network, directing the effort to build a \u201cpre-cancer atlas of skin cancer.\u201d<\/p>\n
Shain\u2019s research has been published in leading journals including Nature, Science, Nature Genetics, The New England Journal of Medicine, Cancer Cell, and Nature Reviews Cancer. His work has been widely profiled in scientific and medical media, underscoring its impact on both fundamental biology and translational cancer research. He has been recognized with numerous awards, including the LEO Foundation Award, the Society of Melanoma Research Young Investigator Award, and selection as one of the American Association for Cancer Research\u2019s Next Generation Stars.[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"
State-of-the-Art Plenary Lecture 3 Friday, May 15, 2:45 \u2013 3:15 PM\u2028\u2028 About Hunter Shain, PhD Dr. Hunter Shain is an Associate Professor in the Department of Dermatology at the University of California, San Francisco (UCSF), where he is also affiliated with the Helen Diller Family Comprehensive Cancer Center and the Institute of Human Genetics. His […]<\/p>\n","protected":false},"author":1,"featured_media":20206482,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"Roger Lo, MD\/PhD","_et_gb_content_width":"","footnotes":""},"categories":[18],"tags":[],"dipi_cpt_category":[],"class_list":["post-20206480","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-2026-annual-meeting-named-lectures"],"yoast_head":"\n